DNA gene mapping
Question:
>The genome project is the first step . It will take 20 – >30 years + to see some targeted genetic therapy. >Dr. Oscar in Italy
I think you’re correct and may even be conservative. If you were confronted with a pile of half a million different aircraft parts and told that you must reconstruct any Boeing aircraft from this pile it would be almost trivial(the total number of different parts in the entire Boeing inventory), because here we have 3 billion labelled parts in a heap at our feet and the task is to reconstruct a human. Awesome. Don’t hold your breath……. Steve. Got questions? Get answers over the phone at Keen.com. Up to 100 minutes free! http://www.keen.com
Response:
It is not one group just looking at the problem at a time, Each research group will prob. get a copy of the genome and they will try to figure out the defect within there field.
Response:
>It is not one group just looking at the problem at a time, Each research group >will prob. get a copy of the genome and they will try to figure out the defect >within there field.
No doubt, but playing the Grinch for a second, I doubt that any gene or group operates in isolation and consider that if the genetic makeup of a particular group of people, for example, is perfectly fine-tuned by evolution over millions of years to survive in Northern Europe in conditions of frequent carbohydrate scarcity, what would we then change this gentic inheritance to become, a Twinkie resistant mutant ? And, if we start changing one gene we may have a domino effect on adjacent genes and end up changing the whole lot, all 3 billion, or we may(probably) solve one problem and create a 1000 more, inadvertantly ? Not saying it can’t be done, but the mind boggles at the size of the task of playing at God. Steve. Got questions? Get answers over the phone at Keen.com. Up to 100 minutes free! http://www.keen.com
Response:
>have a domino effect on adjacent >genes and end up changing the whole lot, all 3 billion, or we >may(probably) solve one problem and create a 1000 more, >inadvertantly ? Not saying it can’t be done, but the mind >boggles at the size of the task of playing at God.
Yes but wouldn’t that be the next natural step in evolution? If man advances to the ability to change our genetics, then we will continue to evolve as a result of this scientcic evolution, right? What do I know. I’m sitting here playing tea party with a very evolved two year old! Nana Ava
Response:
- Hide quoted text — Show quoted text ->It is not one group just looking at the problem at a time, Each >research group >will prob. get a copy of the genome and they will try to figure >out the defect >within there field. >No doubt, but playing the Grinch for a second, I doubt that any >gene or group operates in isolation and consider that if the >genetic makeup of a particular group of people, for >example, is perfectly fine-tuned by evolution over millions of >years to survive in Northern Europe in conditions of frequent >carbohydrate scarcity, what would we then change this gentic >inheritance to become, a Twinkie resistant mutant ? And, if we >start changing one gene we may have a domino effect on adjacent >genes and end up changing the whole lot, all 3 billion, or we >may(probably) solve one problem and create a 1000 more, >inadvertantly ? Not saying it can’t be done, but the mind >boggles at the size of the task of playing at God. >Steve.
go eat your dead mastadons and shut the fuck up for a day Sieze the Carp! Eat a fish today, teach a thousand men to fish for you—Capitalism, it works!"
Response:
– Hide quoted text — Show quoted text ->Today they announced the Book of Life, the Genome project where they map DNA >and can look at one particular gene that causes problems and wipe out. But I >bet you cancer and diabetes come first and psoriasis is last on the list of >things to sort out. Anyone reading this know if they are looking at >psoriasis with this dna mapping thing? > Yeah, they are and have been for quite a while. Things have even been > posted to the ng in the past as individual genetic markers for P have > been identified -there apparently are multiple ones. And BTW, no, they > aren’t saying that they can look at a particular gene causing problems > and just wipe it out for whatever disease. If it was that simple, they > could do it for diseases that they already have pinned down the gene > marker for. This was made pretty clear in any news discussion I’ve > listened to about the genome project. > From the govt’s page on the genome project > http://www.ornl.gov/TechResources/Human_Genome/publicat/hgn/v7n2/2bio… > including P among the diseases they are seeking samples on for > research > From the NPF’s page: > http://www.psoriasis.org/bulletin/28-5/resrndup.html > discussing a bit about the multiple markers and dated 3 years ago, > BTW. > Through a link from the NPF’s page, more at the govt site on familial > genetic susceptibility: > http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?177900 > although that’s a pretty techinical article > NPF press releases on closing in on the gene(s) > http://www.psoriasis.org/media/pressrel.html > Again, from the NPF’s site, links to other genetics resources > involving P on the web > http://www.psoriasis.org/other.html#genetics > Etc. I can find more if you need it, or you should be able to yourself > with some basic searching. To begin with, look at some of the places > turned up on a Northern Lights search: > http://www.northernlight.com/nlquery.fcg?cb=0&qr=psoriasis%2Bgenome&orl= > No, they are not totally ignoring psoriasis in favor of every other > disease in the directory, nor have they been. > Kim
Good answer, Kim. To which I will add that Human Genome Project has almost nothing to do itself with disease research. It’s the effort to determine what each gene controls. Here’s the analogy for where they are right now: they have the globe and some continents and a few countries. They still have a lot of countries, cities, rivers, mountains, etc. left to map. In regard to the effort to indentify the genes involved in psoriasis, the researchers investigating that have made a lot of progress. Although everything I have read and heard talks about Ps being a multi-chromosonal disease, I recently attended a NPF-sponsored meeting where one of the researchers speaking said that it is looking more like that Chromosone 6 is where the "psoriasis gene" resides. And as it has been said before, once those genes are identified, it will still be quite some time before there is any such as direct gene therapy. Will Before you buy.
Response:
> Today they announced the Book of Life, the Genome project where they map DNA > and can look at one particular gene that causes problems and wipe out. But I > bet you cancer and diabetes come first and psoriasis is last on the list of > things to sort out. Anyone reading this know if they are looking at > psoriasis with this dna mapping thing?
The genome project is the first step . It will take 20 – 30 years + to see some targeted genetic therapy. Dr. Oscar in Italy
Response:
> Paul, I agree, and I think part of the reason is that the NPF. is not as >influential or agressive as the other orgs. such as amer. cancer soc. or the >amer. heart assoc.Although I would guess NPF.
While I thoroughly support the NPF and lobbying for psoriasis and pa research, I certainly would be disappointed to see a society that produces research and cures for non-life threatening diseases before cancer, heart disease, diabetes, serious childhood diseases etc., especially based on which lobbying group was the weathiest and loudest! With all due respect to my fellow pa and ps sufferers, we can and do live decent quality lives compared to so many, many other people with terrible diseases. For those who don’t know me, I am about as badly affected by psoriasis and psoriatic arthritis as one can be, but I feel strongly that my life is full and wonderful compared to far more seriously ill people. I do think that independent biologic drug studies will produce much safer and more effective treatment options in the near future, followed by a cure down the road. Just my inflated 2 cents worth! Ava
Response:
>Today they announced the Book of Life, the Genome project where they map DNA >and can look at one particular gene that causes problems and wipe out. But I >bet you cancer and diabetes come first and psoriasis is last on the list of >things to sort out.
I wouldn’t bet the farm on it. Doing the testing on P has the advantage that the results are fairly timely and quite obvious. If the fix works, you will see the results in a short time. Testing on cancer, while it may be more important, will be more difficult to gauge the results. I assume a fix to the dna would not eradicate an existing case of cancer, just prevent new cases. That would require group trials and would be less definitive. M, BATR.. ..Steve Bilan
Response:
>Today they announced the Book of Life, the Genome project where they map DNA >and can look at one particular gene that causes problems and wipe out. But I >bet you cancer and diabetes come first and psoriasis is last on the list of >things to sort out. Anyone reading this know if they are looking at >psoriasis with this dna mapping thing?
Yeah, they are and have been for quite a while. Things have even been posted to the ng in the past as individual genetic markers for P have been identified -there apparently are multiple ones. And BTW, no, they aren’t saying that they can look at a particular gene causing problems and just wipe it out for whatever disease. If it was that simple, they could do it for diseases that they already have pinned down the gene marker for. This was made pretty clear in any news discussion I’ve listened to about the genome project. From the govt’s page on the genome project http://www.ornl.gov/TechResources/Human_Genome/publicat/hgn/v7n2/2bio… including P among the diseases they are seeking samples on for research From the NPF’s page: http://www.psoriasis.org/bulletin/28-5/resrndup.html discussing a bit about the multiple markers and dated 3 years ago, BTW. Through a link from the NPF’s page, more at the govt site on familial genetic susceptibility: http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/dispmim?177900 although that’s a pretty techinical article NPF press releases on closing in on the gene(s) http://www.psoriasis.org/media/pressrel.html Again, from the NPF’s site, links to other genetics resources involving P on the web http://www.psoriasis.org/other.html#genetics Etc. I can find more if you need it, or you should be able to yourself with some basic searching. To begin with, look at some of the places turned up on a Northern Lights search: http://www.northernlight.com/nlquery.fcg?cb=0&qr=psoriasis%2Bgenome&orl= No, they are not totally ignoring psoriasis in favor of every other disease in the directory, nor have they been. Kim
Response:
> Today they announced the Book of Life, the Genome project where they map DNA > and can look at one particular gene that causes problems and wipe out. But I > bet you cancer and diabetes come first and psoriasis is last on the list of > things to sort out. Anyone reading this know if they are looking at > psoriasis with this dna mapping thing?
Paul, While I think that (in the big picture) cancer and diabetes are higher on the list, I think that there are already people working on just psoriasis issues — and so there will be no drain on research brain power for us. I also think that psoriasis is an autoimmune disease like Multiple Sclerosis, Graves Disease, Rheumatoid Arthritis, Lupus, Addison’s disease, etc. There will be crossover research that will weigh on a faster delivery of a psoriasis treatment. — Robb
Response:
> Nevertheless, I would like to see NPF become more vocal and visual, when > was the last time you saw a public service announcement on tv. regarding P ?
There’s exactly one way to make that happen. Go to your checkbook now. Cheer, Jerry J http://www.jhj.com/pbooks/
Response:
Paul writes> > 1bet you cancer and diabetes come first and psoriasis is last> > Paul, I agree, and I think part of the reason is that the NPF. is not as
influential or agressive as the other orgs. such as amer. cancer soc. or the amer. heart assoc.Although I would guess NPF. has just a fraction of the budget of those two groups. Nevertheless, I would like to see NPF become more vocal and visual, when was the last time you saw a public service announcement on tv. regarding P ? (i’ve never seen it). dennis g
Response:
Today they announced the Book of Life, the Genome project where they map DNA and can look at one particular gene that causes problems and wipe out. But I bet you cancer and diabetes come first and psoriasis is last on the list of things to sort out. Anyone reading this know if they are looking at psoriasis with this dna mapping thing?
Response:
Related Posts