Clindamycin?
Question:
>Have you noticed a difference using a systemic approach, Irv?
To Jim and others: Yes, the systemic approach was all that was reall left in the treatment ladder (for me) since about 95% of the skin was affected. With a topical approach, there was not enough time to get all the meds on. (They also did not work out well.) As I have said many times, "With psoriasis, one never really knows." With Cyclosporin, I have little skin activity since May – and yes I am grateful for the relief – for as long as it lasts… Best to all, Irv
Response:
>I wonder haw many subjects are in Dr. Rosenberg’s study with Clindamycin? When >I did research, some 5 years ago, the sample group was very small… I also >came across a Dermie that was trained by Drs. Rosenberg and Skinner and he >seems to lean toward the systemic approach. >Irv—>in Alabama
Have you noticed a difference using a systemic approach, Irv? Jim.
Response:
>Rosenberg and his cow orkers tend to….snip >– Ed "theories need to fit all the facts" Anderson
Psst, ghosts of years ago posts: What’s a cow orker? Jim" running & ducking…oops lost a few hats!(TM)">…>…<…<<<<;-p
Response:
I wonder haw many subjects are in Dr. Rosenberg’s study with Clindamycin? When I did research, some 5 years ago, the sample group was very small… I also came across a Dermie that was trained by Drs. Rosenberg and Skinner and he seems to lean toward the systemic approach. Irv—>in Alabama
Response:
I was a patient of Dr. Rosenberg several years ago. His approach appears to be antibiotics. I tried several mixtures of antibiotics like Clindamycin, Cipro, and several hi-power antifungisides. For me it was not effective at all…. I encourage you to do more research on this subject. The NPF is an excellent source. Irv—>in Alabama
Response:
> If antibiotics or antifungals are effective for you, then by all means > pursue it as a treatment. They aren’t considered useful in most cases, but > are certainly worth a try if you can find a derm who will prescribe them. > There’s always the herbal route, but expect even more side effects.
I’d be interested to know which side effects you are referring to and which herbal remedies provoke them. The only herbal remedy I have tried is Oregon Grape, which has been effective for me and has had no side effects so far, after more than a year and a half. Xan
Response:
>> If antibiotics or antifungals are effective for you, then by all means > pursue it as a treatment. They aren’t considered useful in most cases, but > are certainly worth a try if you can find a derm who will prescribe them. > There’s always the herbal route, but expect even more side effects. > I’d be interested to know which side effects you are referring to and which > herbal remedies provoke them.
I was referring specifcally to antimicrobials. I didn’t want to bring up garlic again, but it does comes to mind. Many prescription drugs are derived from plant origins, even if the active component is now synthesized. As a general rule, "all natural" does not mean "wholesome". Don’t be deceived by marketing hype. The phytoactive properties of herbs can be attributed to the defense toxins that they evolved to defend against parasites. Any plant that had only one defense mechanism, would certainly have died out long ago. When you use a herbal approach for a specific active ingredient, you get the other unwanted toxins along with it. For example, allantoin, which is good for some skin conditions, is an active ingredient in comfrey, which can be deadly. There are many sources of info on the side effects of various herbs. You may not see them listed by the promoters, but that’s because they put a higher priority on making a sale than letting you make an informed decision. In many cases, the side effects aren’t even predictable, because the levels of defense toxins in any one crop depends on what the plants have been challenged with before harvesting. Some plants raised in a hothouse may not live up to their reputations at all. Side effects? Check the FDA neutraceutical adverse reaction database: http://www.pinch.com/skinny?adverse=death Also try a medline search for doctor’s case reports: http://www.pinch.com/skinny?medline=herbal+toxicity > The only herbal remedy I have tried is Oregon > Grape, which has been effective for me and has had no side effects so far, > after more than a year and a half.
I’m sincerely glad to hear that you’ve found something that works for you. Any bebefit from mahonia aquifolium (oregon grape) probably comes from berberine, the active alkaloid. I remember researching it and posting that it inhibits lipoxygenase, a key enzyme in the breakdown cascade of arachidonic acid to a b4 white blood cell inflammatory response. Despite the recent promotions since then, I think you’re the first to mention personal success. Maybe you could describe your regimen in more detail. How do you use the herb? How long was it before you noticed any benefit? DaveW’s pages have info on mahonia, and describe some known side effects of other herbal psoriasis treatments that he’s reviewed: http://members.aol.com/psorsite/herbals.html Note that chaparral (creosote bush) is sold as a P treatment, and it contains an alkaloid which is a lipoxygenase inhibitor, but it is responsible for several cases of fatal liver damage. I’m not aware of any problems with mahonia, but please be aware of possible side effects. Personally, I use topical anthralin. It’s the synthetic form of one of the earliest herbal treatments, Goa powder. The Portugese exported the powdery residue from the brazilian araroba tree to the trade island of Goa. From there, it made its way to Europe. It lost much of its potency as it oxidized during shipping. It was synthesized by Bayer during WWI, when the supply became scarce. It remained a primary treatment for psoriasis (along with other "natural" treaments mercury and arsenic) until tar and ultraviolet therapy became popular. Low dose anthralin (Drithocreme 0.1%) seems to be just as effective for me now as it was when I first started using it a couple of years ago. — Ed "I like to know what goes into my temple" Anderson
Response:
> I have read some posts on Dr. Rosenberg’s study in TN-Memphis and > recently received his study from there to review about studying the > effects on chronic P patients with a well known drug called > Clindamycin. Has anyone participated in this study, had positive > results or gone on this drug at all?
Check the archives at http://www.pinch.com/skinny?deja=clindamycin I’ve tried antibiotics and antifungals, in combination and separately. Antifungals help some people, but not me. I’ve seen an initial change in my skin with the antibiotic. The lesions become more pinkish (usually a sign of improvement) and the plaques become more granular (tiny flakes). Unfortunately, it doesn’t improve beyond that. I’ve chalked it up to possibly nuking some opportunistic bacteria, and possibly a photosensitization effect, since I’ve felt a lasting pins and needles effect after getting my usual dose of sun. http://www.pinch.com/skinny?deja=antibiotics > It seems that 58% reported clearing and now he is trying to > scientifically prove this via his research/placebo tests….Any > feedback is appreciated as I would like to share this with my local > Dermy to see if he would go down this path with me.
Most doctors are reluctant to prescribe antibiotics without good cause, because that practice is responsible for the evolution of resistant bacterial strains. It’s a serious problem in hospitals. Don’t get hung up on Clindamycin. That was one small study. Rosenberg has recommended treatment with many other drugs. He claims to have identified various organisms for each form of psoriasis. Rosenberg and his coworkers tend to generate controversy. IMHO, they make sweeping statements in their medical journal reports, with insufficient basis for their claims of microorganisms as a primary basis for psoriasis. This may be because of the difference between the way clinicians and scientific researchers approach psoriasis. Their theories have more appeal in popular literature than in the research arena. Rosenberg is also involved with commercial development and testing of the "At Last" brand topical steroid spray, and has tried to patent what is essentially a clone of Skin-Cap, already on the market. If systemic antimicrobials were an effective approach, one would expect a the doctors to be pursuing that rather than developing me-too topical products. http://www.pinch.com/skinny?medline=rosenberg+psoriasis > I am willing to give most things a shot at this point besides the > heavier drugs (no offense to anyone )since i am rather young.
If antibiotics or antifungals are effective for you, then by all means pursue it as a treatment. They aren’t considered useful in most cases, but are certainly worth a try if you can find a derm who will prescribe them. There’s always the herbal route, but expect even more side effects. Good luck, and let us know how you fare. — Ed "theories need to fit all the facts" Anderson
Response:
I have read some posts on Dr. Rosenberg’s study in TN-Memphis and recently received his study from there to review about studying the effects on chronic P patients with a well known drug called Clindamycin. Has anyone participated in this study, had positive results or gone on this drug at all? It seems that 58% reported clearing and now he is trying to scientifically prove this via his research/placebo tests….Any feedback is appreciated as I would like to share this with my local Dermy to see if he would go down this path with me. I am willing to give most things a shot at this point besides the heavier drugs (no offense to anyone )since i am rather young. thanks Before you buy.
Response:
Related Posts