uvb treatment

Question:

I work with Dr. povzner. He work with UVB for 30 years, starting with the russian army, and now in some big hospitals in Israel. I asked him if he knows of one person who got cancer from UVB, he said no. — Regards Gil Gil Teva 20 Mekor Haim street Jerusalem 93465 Israel Tel: +972 2 6724273 Mobile: +972-54-948642

– Hide quoted text — Show quoted text -> >Can anyone advise me on this.  My derm stated that once i start getting > >these treatments, I will see almost immediate improvement. > (snip) > Well, I’ve babbled quite a bit here, and maybe you already knew some > or all of this, but it does seem like there is rather more hope these > days than even ten years ago, hey, even three years ago.  Try the UVB, > maybe you’ll get lucky and you can ignore the rest of these potions! > Better days, > J. > Sorry JR, I didn’t see this post before I replied to an earlier one from > you. > —

Response:

> >Can anyone advise me on this.  My derm stated that once i start getting >these treatments, I will see almost immediate improvement. (snip) > Well, I’ve babbled quite a bit here, and maybe you already knew some > or all of this, but it does seem like there is rather more hope these > days than even ten years ago, hey, even three years ago.  Try the UVB, > maybe you’ll get lucky and you can ignore the rest of these potions! > Better days, > J.

Sorry JR, I didn’t see this post before I replied to an earlier one from you. —

Response:

>JR, don’t you think it’s better to risk the skin cancer than take all >the internal meds though?

It depends.  What it means is that just because an internal med has some risk, well, so does the UV, so what do you do, toss a coin? For me, right now, I’m going with the UV, that’s all I can say. > I’d much rather do this treatment than the steroids and >internal meds. When I was using the steroids my wrist was bleeding every >day under my watch band. I would scratch my legs till I bled and my >black knee high stockings would turn white with flakes. That is all gone >and it is such a great relief.

I too had terrible luck with steroids. J.

Response:

>> Methotrexate is an old drug, only started using it for psoriasis about > twenty (?) years ago, and they’re still working on the best way to >Methotrexate is not that new for P.  My derm at the time, sometimwe before >1965, tried it on me when it was a brand new drug that would solvwe all the >problems of leukemia, etc.  It worked after a fasion, but the dosage neefef >for clearing caused too much a drop in white blood cell count.  That was >long before liver monitoring.   He tried Methotrexate after its predicessor, >Amethopterin,  showed some promise with P, but was much too toxic for >continued use.

Thanks for the first-hand report!  Another reader also emailed me a message with a pre-1970 experience.  I guess it’s more like thirty years plus, with another twenty years before that for experiments. I found this: http://www.skincareguide.com/SkinTherapyLetterV6N03.pdf In 1951 Gubner reported improvement in psoriatics treated with the folate antagonist aminopterin, but clinical use was limited by mucosal and GI side-effects. In 1958, Edmundson and Guy reported good control of psoriasis with amethopterin, or methotrexate (MTX), an analog of aminopterin. … Studies in animals demonstrated that MTX toxicity was more closely related to duration of contact with tissues than with total dose, and in 1963, Berlin suggested that an intermittent dosage schedule might improve the therapeutic index. — I thought they only got the dosages down to current levels circa 1980, … but it’s just a fuzzy recollection that I read that somewhere, your experience may prove otherwise! Elsewhere, I see a claim that mtx was the first internal drug used for psoriasis.  I wonder about that statement, tho. J.

Response:

> >UVB is known as the best effective treatment, mainly because there are no >side effects. > Except skin cancer and stuff.  Better than PUVA, but even so. > J.

JR, don’t you think it’s better to risk the skin cancer than take all the internal meds though? I’m not contradicting what you say, asking an honest opinion. However, I say this ONLY if one continues to see their derm regularly in case anything suspicious pops up, which is what I’m doing. I’d much rather do this treatment than the steroids and internal meds. When I was using the steroids my wrist was bleeding every day under my watch band. I would scratch my legs till I bled and my black knee high stockings would turn white with flakes. That is all gone and it is such a great relief. I would think it’d be worth a shot before going to all the internal meds that can damage organs, etc. Maybe I’m wrong here, but it sure seems to be the best option for me. —

Response:

> Methotrexate is an old drug, only started using it for psoriasis about > twenty (?) years ago, and they’re still working on the best way to

Methotrexate is not that new for P.  My derm at the time, sometimwe before 1965, tried it on me when it was a brand new drug that would solvwe all the problems of leukemia, etc.  It worked after a fasion, but the dosage neefef for clearing caused too much a drop in white blood cell count.  That was long before liver monitoring.   He tried Methotrexate after its predicessor, Amethopterin,  showed some promise with P, but was much too toxic for continued use.

Response:

Today. Most of the systems shipped to Derms are Narrow Band UVB not Broadband UVB. I clipped the following from www.uv-light.com  for you. "Narrow Band photo-therapy cabinets and panels solve the problems of over-exposure to ultraviolet by maximizing delivery of narrow-band UVB radiation (in the 311-312 nm range, the most beneficial component of natural sunlight) while minimizing exposure to superfluous UV. This allows patients to receive photo-therapy treatments with less risk of severe burning or pathogenic exposure to UV in harmful ranges. (It also avoids the adverse side effects of the psoralens used in conventional PUVA therapy, since UVB treatment requires no supplemental drugs.) These therapeutic benefits have made Daavlins Narrow Band UVB photo-therapy systems into the fastest-selling series of photo-therapy cabinets among dermatologists throughout Europe, Asia, and the Pacific Rim. Now they

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